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张阿梅(A-Mei Zhang)


时间:2014年04月11日信息来源:本站原创 点击: 【字体:

张阿梅(A-Mei Zhang)
1980年2月生,博士,副教授
E-mail: zam1980@yeah.net 

 


受教育经历
1997.9 ~2002.7    内蒙古民族大学临床医学院临床医学专业   医学学士
2004.9~2007.7     贵阳医学院病原生物学专业               医学硕士
2007.9~2011.1     中国科学院昆明动物研究所               理学博士


 

主要研究方向
 

     主要致力于遗传疾病及感染传染性疾病的遗传易感研究。探索遗传疾病的致病基因及其致病机理,从而为临床遗传性疾病的人群筛查和遗传咨询提供理论依据;发现感染性疾病的病原菌与宿主相互作用的蛋白,阐明病原菌致病的机理,为该类疾病的临床治疗和药物研发奠定基础。

承担科研项目情况
国家自然科学基金青年基金项目(批准号:81200725)

获奖情况
2010年   中国科学院“朱李月华”优秀博士生奖学金

代表性论文和专著
1.  Zhang A-M, Jia X, Guo X, Zhang Q, Yao Y-G. Mitochondrial DNA mutation m.10680G >A is associated with Leber hereditary optic neuropathy in Chinese patients. J Transl Med. 2012, 9;10:43.
2. Zhang A-M, Jia X, Bi R, Salas A, Li S, Xiao X, Wang P, Guo X, Kong Q-P, Zhang Q,Yao Y-G. Mitochondrial DNA haplogroup background affects LHON, but not suspectedLHON, in Chinese patients. PLoS ONE. 2011, 6(11):e27750.
3.  Zhang A-M, Bandelt H-J, Jia X, Zhang W, Li S, Yu D, Wang D, Zhuang X-Y, Zhang Q, Yao Y-G. Is mitochondrial tRNA(phe) variant m.593T>C a synergistically pathogenic mutation in Chinese LHON families with m.11778G>A? PLoS ONE. 2011, 6(10):e26511.
4.  Zhang A-M, Jia X, Zhang Q, Yao Y-G. No association between the SNPs (rs3749446 and rs1402000) in the PARL gene and LHON in Chinese patients with m.11778G>A. Hum Genet. 2010, 128(4):465-468.
5.  Zhang A-M, Zou Y, Guo X, Jia X, Zhang Q, Yao Y-G. Mitochondrial DNA mutation m.3635G>A may be associated with Leber hereditary optic neuropathy in Chinese. Biochem Biophys Res Commun. 2009, 21;386(2):392-395.
6.  Ji Y*, Zhang A-M*, Jia X, Zhang Y-P, Xiao X, Li S, Guo X, Bandelt H-J, Zhang Q, Yao Y-G. Mitochondrial DNA haplogroups M7b1'2 and M8a affect clinical expression of leber hereditary optic neuropathy in Chinese families with the m.11778G>A mutation. Am J Hum Genet. 2008, 83(6):760-768. (*co-first authors)
7.  Zhang A-M, Jia X, Yao Y-G, Zhang Q. Co-occurrence of A1555G and G11778A in a Chinese family with high penetrance of Leber's hereditary optic neuropathy. Biochem Biophys Res Commun. 2008, 376(1):221-224.
8.   Guo H, Zhuang X-Y, Zhang A-M, Zhang W, Yuan Y, Guo L, Yu D, Liu J, Yang DK, Yao Y-G. Presence of mutation m.14484T>C in a Chinese family with maternally inherited essential hypertension but no expression of LHON. Biochim Biophys Acta. 2012, 1822(10):1535-1543.
9.   Wang D, Su LY, Zhang A-M, Li YY, Li XA, Chen LL, Long H, Yao Y-G. Mitochondrial DNA copy number, but not haplogroup, confers a genetic susceptibility to leprosy in Han Chinese from Southwest China. PLoS ONE. 2012, 7(6):e38848.
10.  Bi R, Zhang A-M, Yao Y-G. Leber's hereditary optic neuropathy. Ophthalmology. 2011, 118(7):1489-1489.
11.  Peng M-S, Palanichamy M-G, Yao Y-G, Mitra B, Cheng Y-T, Zhao M, Liu J, Wang HW, Pan H, Wang W-Z, Zhang A-M, Zhang W, Wang D, Zou Y, Yang Y, Chaudhuri T-K, Kong Q-P, Zhang Y-P. Inland post-glacial dispersal in East Asia revealed by mitochondrial haplogroup M9a'b. BMC Biol. 2011, 10;9:2.
12.  Yu D, Jia X, Zhang A-M, Li S, Zou Y, Zhang Q, Yao Y-G. Mitochondrial DNA sequence variation and haplogroup distribution in Chinese patients with LHON and m.14484T>C. PLoS ONE. 2010, 18;5(10):e13426.
13.  Zou Y, Jia X, Zhang A-M, Wang W-Z, Li S, Guo X, Kong Q-P, Zhang Q, Yao Y-G. The MT-ND1 and MT-ND5 genes are mutational hotspots for Chinese families with clinical features of LHON but lacking the three primary mutations. Biochem Biophys Res Commun. 2010, 20;399(2):179-185.
14.  Bi R, Zhang A-M, Yu D, Chen D, Yao Y-G. Screening the three LHON primary mutations in the general Chinese population by using an optimized multiplex allele-specific PCR. Clin Chim Acta. 2010, 11;411(21-22):1671-1674.
15.  Yu D, Jia X, Zhang A-M, Guo X, Zhang Y-P, Zhang Q, Yao Y-G. Molecular characterization of six Chinese families with m.3460G>A and Leber hereditary optic neuropathy. Neurogenetics. 2010, 11(3):349-356.
16. Bi R, Zhang A-M, Zhang W, Kong Q-P, Wu B-L, Yang XH, Wang D, Zou Y, Zhang Y-P, Yao Y-G. The acquisition of an inheritable 50-bp deletion in the human mtDNA control region does not affect the mtDNA copy number in peripheral blood cells. Hum Mutat. 2010, 31(5):538-543.



 


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